Long-term food restriction prevents aging-associated sphingolipid turnover dysregulation in the brain

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dc.contributor.authorBabenko, N. A.
dc.contributor.authorБабенко, Н. А.
dc.contributor.author
dc.contributor.authorShakhova, E. G.
dc.contributor.authorШахова, О. Г.
dc.contributor.authorШахова, Е. Г.
dc.contributor.authorORCID: http://orcid.org/0000-0002-7860-6972
dc.date.accessioned2019-01-15T19:23:30Z
dc.date.available2019-01-15T19:23:30Z
dc.date.issued2014
dc.descriptionBabenko, N. A. Long-term food restriction prevents aging-associated sphingolipid turnover dysregulation in the brain / Nataliya A. Babenko, Elena G. Shakhova // Archives of Gerontology and Geriatrics. - 2014. - Volume 58, Issue 3 (May–June). - P. 420-426.
dc.description.abstractДосліджено порушення обміну сфинголипидов в головному мозку під час нормального старіння і вікові неврологічні розлади, які були пов'язані з втратою нейронів і когнітивними порушеннями.uk_UA
dc.description.abstractAbnormalities of sphingolipid turnover in the brain during normal aging and age-related neurological disorders were associated with the neurons loss and cognitive malfunction. Calorie restriction (CR) prevented age-related deficits in hippocampal long-term potentiation and improved cognitive function at old age. In the paper we investigated the ceramide and sphingomyelin (SM) levels in the brain regions, which are critical for learning and memory of 3- and 24-month-old rats, as well as the correction of sphingolipid turnover in the brain of old rats, by means of the CR diet and modulators of SM turnover. Using the [methyl-14C-choline]SM, the neutral, but not the acid SMase activity has been observed to increase in both the hippocampus and brain cortex of 24-month-old rats with respect to 3-month-old animals. Age-dependent changes of neutral SMase activities were associated with ceramide accumulation and SM level drop in the brain structures studied. Treatment of the rats with the CR diet or N-acetylcysteine (NAC) or α-tocopherol acetate, but not an inhibitor of acid SMase imipramine, reduced the ceramide content and neutral SMase activity in the hippocampus of 24-month-old animals with respect to control rats of the same age. These results suggest that redox-sensitive neutral SMase plays important role in SM turnover dysregulation in both the hippocampus and neocortex at old age and that the CR diet can prevent the age-dependent accumulation of ceramide mainly via neutral SMase targetingen
dc.description.abstractИсследованы нарушения обмена сфинголипидов в головном мозге во время нормального старения и возрастные неврологические расстройства, которые были связаны с потерей нейронов и когнитивными нарушениями.ru
dc.identifier.urihttp://dspace.univd.edu.ua/xmlui/handle/123456789/4537
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0167494313001970
dc.identifier.urihttps://doi.org/10.1016/j.archger.2013.12.005
dc.language.isoenuk_UA
dc.publisherArchives of Gerontology and Geriatrics. - 2014. - Volume 58, Issue 3 (May–June). - P. 420-426uk_UA
dc.subjectpublikatsii u Scopus
dc.subjectpublikatsii u zarubizhnomu vydanni
dc.subjectгеронтология
dc.subjectгериатрия
dc.subjectaging
dc.subjectcalorie restricted diet
dc.subjectsphingomyelin turnover
dc.subjectbrain
dc.subjectN-acetylcysteine
dc.subjectα-Tocopherol acetate
dc.subjectНаукові публікації. Scientific publications. Научные публикации
dc.subjectN-ацетилцистеин
dc.subjectМедичні науки. Medical sciences. Медицинские науки
dc.subjectбіологія людини
dc.titleLong-term food restriction prevents aging-associated sphingolipid turnover dysregulation in the brainuk_UA
dc.typeArticleuk_UA

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Наукові публікації (Scientific publications). УДК 61(045)