Effectiveness of anti-tuberculosis chemotherapy in patients with tuberculosis relapse compared with newly diagnosed patients

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dc.contributor.authorButov, D.
dc.contributor.authorGumenuik, M.
dc.contributor.authorGumenuik, G.
dc.contributor.authorTkachenko, A.
dc.contributor.authorKikinchuk, V. V.
dc.contributor.authorКікінчук, В. В.
dc.contributor.authorORCID: http://orcid.org/0000-0003-2241-6384
dc.contributor.authorResearcherID: E-7775-2019
dc.contributor.authorStepaniuk, R. L.
dc.contributor.authorСтепанюк, Р. Л.
dc.contributor.authorORCID: http://orcid.org/0000-0002-8201-4013
dc.contributor.authorPeshenko, O. M.
dc.contributor.authorПешенко, О. М.
dc.contributor.authorButova, T.
dc.date.accessioned2020-05-20T18:28:09Z
dc.date.available2020-05-20T18:28:09Z
dc.date.issued2020
dc.descriptionEffectiveness of anti-tuberculosis chemotherapy in patients with tuberculosis relapse compared with newly diagnosed patients / Dmytro Butov, Mykola Gumenuik, Galyna Gumeniuk and oth. // International Journal of Mycobacteriology. – 2019. – Vol. 8, Issue 4 (October-December). – P. 341-346. – DOI: 10.4103/ijmy.ijmy_158_19.uk_UA
dc.descriptionButov D, Gumenuik M, Gumeniuk G, Tkachenko A, Kikinchuk V, Stepaniuk R, Peshenko A, Butova T. Effectiveness of anti-tuberculosis chemotherapy in patients with tuberculosis relapse compared with newly diagnosed patients. Int J Mycobacteriol 2019;8:341-6
dc.descriptionButov D, Gumenuik M, Gumeniuk G, Tkachenko A, Kikinchuk V, Stepaniuk R, Peshenko A, Butova T. Effectiveness of anti-tuberculosis chemotherapy in patients with tuberculosis relapse compared with newly diagnosed patients. Int J Mycobacteriol [serial online] 2019 [cited 2020 May 20];8:341-6. Available from: http://www.ijmyco.org/text.asp?2019/8/4/341/271478
dc.description.abstractГоловна мета статті - вивчити ефективність антитуберкульозної хіміотерапії у пацієнтів з рецидивом туберкульозу легень порівняно з пацієнтами з недавно діагностованим процесом.uk_UA
dc.description.abstractBackground: To study the effectiveness of antituberculosis chemotherapy in patients with relapse pulmonary tuberculosis (RTB) compared with patients with the newly diagnosed process. Methods: We examined 285 TB patients, including 126 individuals with RTB (Group 1) and 159 patients with newly diagnosed pulmonary tuberculosis (NDPTB) (Group 2). All patients were diagnosed with infiltrative PTB. Effectiveness of the basic course of antimycobacterial treatment was assessed in accordance with the following data: time required for the normalization of clinical manifestations, smear conversion, cavity healing, disappearance of infiltrative and focal changes in the pulmonary tissue, as well as the final clinical effectiveness of therapy. Results: Disappearance of clinical symptoms was statistically significantly faster in Group 2 compared with RTB patients in 2.25 ± 0.11 and 3.40 ± 0.15 months, respectively (P < 0.001). Sputum culture conversion was observed after 6 months of treatment in 138 (86.79%) patients with NDPTB and 89 (72.22%) patients from Group 1 (P = 0.0023). Closure of cavities and disappearance of infiltrative and focal changes in the lungs occurred within 6 months of chemotherapy only in 55 (43.65%) patients with RTB and 93 (58.49%) patients with NDPTB (P = 0.0133). Conclusions: Standard treatment for patients with NDPTB is considered successful in case of faster health improvement and stabilization, less pronounced rates of toxic adverse reactions to antiTB drugs, faster sputum smear and culture conversion and cavity healing, signs of clinical and radiological convalescence, and the reduced number of large residual changes after the treatment compared with RTB.en
dc.description.abstractГлавная цель статьи - изучить эффективность антитуберкулезной химиотерапии у пациентов с рецидивом туберкулеза легких по сравнению с пациентами с недавно диагностированным процессом.ru
dc.identifier.urihttp://dx.doi.org/10.4103/ijmy.ijmy_158_19
dc.identifier.urihttp://www.ijmyco.org/text.asp?2019/8/4/341/271478
dc.identifier.urihttp://dspace.univd.edu.ua/xmlui/handle/123456789/8935
dc.language.isoenuk_UA
dc.publisherInternational Journal of Mycobacteriology. – 2019. – Vol. 8, Issue 4 (October-December). – P. 341-346
dc.subjectpublikatsii u zarubizhnomu vydanniuk_UA
dc.subjectpublikatsii u WoSuk_UA
dc.subjectpulmonary tuberculosis relapseuk_UA
dc.subjecttreatmentuk_UA
dc.subjecttuberculosisuk_UA
dc.subjecttuberculosis treatment effectivenessuk_UA
dc.subjectКриміналістика. Criminalistics. Криминалистикаuk_UA
dc.subjectНаукові публікації. Scientific publications. Научные публикацииuk_UA
dc.subjectМедичні науки. Medical sciences. Медицинские наукиuk_UA
dc.subjectтуберкульозuk_UA
dc.subjectтуберкулезuk_UA
dc.subjectforensic medical examinationuk_UA
dc.titleEffectiveness of anti-tuberculosis chemotherapy in patients with tuberculosis relapse compared with newly diagnosed patientsuk_UA
dc.typeArticleuk_UA

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Наукові публікації (Scientific publications). УДК 61(045)